Elastography in Preclinical Research
As techniques for elastography grow more quantitative, more sensitive, and more available to pre-clinical researchers, our ability to track changes in specific tissues is greatly increased. Presumably, long term changes (over weeks or months) are attributable to alterations in tissue structure and composition, for example in the case of progressive fibrosis in liver tissue. However, there are also short term changes that can occur due to a variety of physiological parameters. We compare these two types of changes and relate some of the short term alterations in tissue stiffness to the state of fluids in microchannels within the soft tissue. Experimental and theoretical results are given to highlight the different time-scales over which the elastic properties of tissues can change; rapidly or slowly.